2 hours to Paris (trains run every 90 mins), 3 hours to Lille, 5 hours to London (Eurostar).
The TGV trains from Lyon also go to Chambéry, Anneccy and Brussels.
The TGV Méditerranée links Lyon to Marseille in 1 hour 40 mins (21 daily return trips)
Information for Part-Dieu & Perrache stations and Lyon Saint Exupéry airport: www.voyages-sncf.com
General information about Regional public transport: www.multitud.org